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When interpreting the current results for clinical use, a few limitations should be considered

LRRK2 is located mainly in the cytoplasm, although approximately 10% of LRRK2 is located to the mitochondria and regulates mitochondrial function ( LRRK2 mutations in DA neurons were associated with an increased susceptibility to oxidative stress ( VPS35 Vacuolar protein sorting 35 (VPS35), composed of 796 amino acids, is a core component of the retromer complex and participates in endosomal-lysosomal transport

doi: 10.1016/j.jid.2017.08.038 106 NizardMRousselHDinizMOKarakiSTranTVoronTet al

[Rhamnaceae] (Yi et al., 2014)

Also cereals have been studied as substrate for lactic acid fermentation